Children’s exposure to intimate partner violence (IPV) is now recognized as a form of child maltreatment associated with significant mental health impairment. This article provides an overview of the epidemiology of children’s exposure to IPV, including prevalence, risk, and protective factors and associated impairment, and a summary of assessment and interventions aimed at preventing its occurrence and responding to children and families. Information about evidence-based approaches to responding to children who present with impairment after exposure to IPV, such as posttraumatic-stress disorder symptoms, is discussed. Some of the challenges in understanding children’s needs with regard to safety and protection are outlined with recommendations for future directions.